Unterschiede

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--- asarum_sieboldii_miq [2015/06/30 14:17] – andreas
+++ asarum_sieboldii_miq [2015/12/22 06:41] (aktuell) – andreas
@@ Zeile 13: / Zeile 13: @@
 [Hager; Fujita Y, Bot.Mag.Tokyo, 79, (1966), 783-790]
-"The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenami de (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD4."\\
+"The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD4."\\
 [Studies on anti-allergic components in the roots of Asiasarum sieboldi., Hashimoto, K., Yanagisawa, T., Okui, Y., Ikeya, Y., Maruno, M., Fujita, T., Planta medica, 60(2), 1994, 124-127]
+The amounts of [[https://en.wikipedia.org/wiki/Aristolochic_acid|aristolochic acid I]] and II (associated with a high incidence of uroepithelial tumorigenesis) in four groups of medicinal plants from the Aristolochiaceae and some related plants were determined by some researchers. Differnet amounts of them were found in Asarum heterotropoides var. mandshuricum, Asarum sieboldii (Usuba-saishin), Asarum heterotropoides (Keirin–saishin), Asarum sieboldii var. seoulense (Usuge-saishin) and commercial `Saishin' Asarum sect. Asiasarum sp. (Korean market), ranging from none to troubling 142 µg/g. \\
+[Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants., Hashimoto, K., Higuchi, M., Makino, B., Sakakibara, I., Kubo, M., Komatsu, Y., Okada, M., Journal of ethnopharmacology, 64(2), 1999, 185-189] \\
+[Determination of aristolochic acid A in Radix Aristolociae and Herba Asari by RP-HPLC., Jiang, X., Wang, Z.M., You, L.S., Dai, L.P., Ding, G.Z., Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica, 29(5), 2004, 408-410] \\
+[[http://www.ctca.de/index.php/en/archive/the-safety-of-asarum-an-evaluation-by-axel-wiebrecht]]
 "...the methanol extract of AR exerts anti-nociceptive and anti-inflammatory effects by activating opioid receptor as well as by inhibiting bradykinin and histamine-mediated actions." \\
 [Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways., Kim, S.J., Zhang, C.G., Lim, J.T., Journal of ethnopharmacology, 88(1), 2003, 5-9]
-" ...the content of safrole in the dried herbal drugs tested ranged from 0.14–2.78 mg/ g whilst the content of methyleugenol ranged from 1.94–16.04 mg/g... The present study demonstrated that following a 1-hour decoction, the amount of safrole was decreased by more than 92% resulting in the equivalent of no more than 0.20 mg/g safrole remaining in the aqueous extract. Similarly, the content of methyleugenol was decreased to the equivalent of 0.30–2.70 mg/g. Furthermore, both TCM formulae, after decoction, showed negligible amounts of safrole (maximum, the equivalent of 0.06 mg/ g), and only 1.38–2.71 mg/g of methyleugenol... The present study shows that a decoction procedure, similar to that traditionally used for Chinese herbal preparations, is able to effectively reduce the amount of safrole and methyleugenol effectively. Such a reduction in the content of safrole should be acceptable for therapeutic use." \\
+" ...the content of safrole in the dried herbal drugs tested ranged from 0.14–2.78 mg/ g whilst the content of methyleugenol ranged from 1.94–16.04 mg/g... following a 1-hour decoction, the amount of safrole was decreased by more than 92% resulting in the equivalent of no more than 0.20 mg/g safrole remaining in the aqueous extract. Similarly, the content of methyleugenol was decreased to the equivalent of 0.30–2.70 mg/g. Furthermore, both TCM formulae, after decoction, showed negligible amounts of safrole (maximum, the equivalent of 0.06 mg/ g), and only 1.38–2.71 mg/g of methyleugenol... The present study shows that a decoction procedure, similar to that traditionally used for Chinese herbal preparations, is able to effectively reduce the amount of safrole and methyleugenol effectively. Such a reduction in the content of safrole should be acceptable for therapeutic use." \\
 [Reduction of safrole and methyleugenol in Asari radix et rhizoma by decoction., Chen, C., Spriano, D., Lehmann, T., Meier, B., Forschende Komplementärmedizin/Research in Complementary Medicine, 16(3), 2009, 162-166]
+pictures: [[http://www.asianflora.com/Aristolochiaceae/Asarum-sieboldii.htm]]