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--- centella_asiatica_l._urb [2015/09/26 11:14] – andreas
+++ centella_asiatica_l._urb [2015/09/26 12:22] (aktuell) – andreas
@@ Zeile 7: / Zeile 7: @@
 "It is used as a medicinal herb in Ayurvedic medicine, traditional African medicine, and traditional Chinese medicine... Centella is used as a leafy green in Sri Lankan cuisine, where it is called gotu kola. In Sinhalese, gotu is translated as "conical shape" and kola as "leaf". It is most often prepared as malluma (මැල්ලුම), a traditional accompaniment to rice and curry, and goes especially well with vegetarian dishes, such as dhal, and jackfruit or pumpkin curry." [[https://en.wikipedia.org/wiki/Centella_asiatica]]
-"Asiaticoside derived from the plant Centella asiatica is known to possess good wound healing activity... Asiaticoside application (0.2%, topical) twice daily for 7 days to excision-type cutaneous wounds in rats led to increased enzymatic and non-enzymatic  antioxidants,  namely  superoxide  dismutase  (35%),  catalase  (67%),  glutathione  peroxidase  (49%), vitamin E (77%) and ascorbic acid (36%) in newly formed tissues. It also resulted in a several fold decrease  in  lipid  peroxide  levels  (69%)  as  measured  in  terms  of  thiobarbituric  acid  reactive  substance. However,  continued application  for  14 days showed no  significant difference  in  these  antioxidants compared with their values in vehicle treated wound tissue. It appears from the present study that asiaticosides enhanced induction of  antioxidant levels  at an initial  stage of healing  which may be  an important contributory factor in the healing properties of this substance." \\
+α-Humulene (21.0%), β-caryophyllene (19.0%), bicyclogermacrene (11.2%), germacrene B (6.2%), and myrcene (6.5%) were the predominant constitutes of the essential oil of C.asiatica. \\
-[Asiaticoside‐induced elevation of antioxidant levels in healing wounds., Shukla, A., Rasik, A.M., Dhawan, B.N., Phytotherapy Research, 13(1), 1999, 50-54]
-α-Humulene (21.0%), β.-caryophyllene (19.0%), bicyclogermacrene (11.2%), germacrene B (6.2%), and myrcene (6.5%) were the predominant constitutes of the essential oil of C.asiatica. \\
 [Chemical composition and antibacterial activity of the essential oil of Centella asiatica growing in South Africa., Oyedeji, O.A., Afolayan, A.J., Pharmaceutical Biology, 43(3), 2005, 249-252]
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 Fresh juice was characterized by a high content of the oxygenated monoterpenes; linalool (335.5 ng/L), geraniol (146.9 ng/L) and β-cyclocitral (42.5 ng/L) and the sesquiterpenoid hydrocarbons β-caryophyllene (1344.0 ng/L) and humulene (1602.2 ng/L) were present at higher concentrations in the fresh juice than other volatiles." \\
 [Flavour characterisation of fresh and processed pennywort (Centella asiatica L.) juices., Wongfhun, P., Gordon, M.H., Apichartsrangkoon, A., Food chemistry, 119(1), 2010, 69-74] [[http://centaur.reading.ac.uk/4634/1/Flavour_Paper_2_final_full_paper.doc]]
+----
+"Asiaticoside derived from the plant Centella asiatica is known to possess good wound healing activity... Asiaticoside application (0.2%, topical) twice daily for 7 days to excision-type cutaneous wounds in rats led to increased enzymatic and non-enzymatic  antioxidants,  namely  superoxide  dismutase  (35%),  catalase  (67%),  glutathione  peroxidase  (49%), vitamin E (77%) and ascorbic acid (36%) in newly formed tissues. It also resulted in a several fold decrease  in  lipid  peroxide  levels  (69%)  as  measured  in  terms  of  thiobarbituric  acid  reactive  substance. However,  continued application  for  14 days showed no  significant difference  in  these  antioxidants compared with their values in vehicle treated wound tissue. It appears from the present study that asiaticosides enhanced induction of  antioxidant levels  at an initial  stage of healing  which may be  an important contributory factor in the healing properties of this substance." \\
+[Asiaticoside‐induced elevation of antioxidant levels in healing wounds., Shukla, A., Rasik, A.M., Dhawan, B.N., Phytotherapy Research, 13(1), 1999, 50-54]
+"Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as centelloids. These terpenoids include asiaticoside, centelloside, madecassoside, brahmoside, brahminoside, thankuniside, sceffoleoside, centellose, asiatic-, brahmic-, centellic- and madecassic acids. The triterpene saponins are common secondary plant metabolites and are synthesized via the isoprenoid pathway to produce a hydrophobic triterpenoid structure (aglycone) containing a hydrophilic sugar chain (glycone)... Various saponins occur in C. asiatica due to the location and diverse environmental conditions..." \\
+[Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban., James, J.T., Dubery, I.A., Molecules, 14(10), 2009, 3922-3941] [[http://www.mdpi.com/1420-3049/14/10/3922/pdf]]
 "Most of the clinical studies on Asian CA have been realized with alcoholic or aqueous extracts. The TECA extracts (titrated extracts of Asian CA and TTFCA (triterpenic total fraction of Asian CA) are combinations of asiatic acid (30%), madecasic acids (30%) and asiaticoside (40%). The TTF extract (triterpenic total fraction) consists of Asian CA and madecasic acids (60%) in a relation not clearly defined yet, in combination with asiaticoside (40%)." \\